Regioselective rhodium-catalyzed intermolecular [2+2+2] cycloaddition of alkynes and isocyanates to form pyridones
نویسندگان
چکیده
منابع مشابه
Rhodium(III)-catalyzed intermolecular hydroarylation of alkynes.
The rhodium(III)-catalyzed hydroarylation of internal alkynes is described. Good yields are obtained for a variety of alkynes, and excellent regioselectivity is observed for unsymmetrically substituted alkynes. The reaction also gives good yields for a range of arenes. Preliminary mechanistic investigations suggest that this reaction proceeds through arene metalation with the cationic rhodium c...
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A novel rhodium-catalyzed linear codimerization of alkyl phenyl ketenes with internal alkynes to dienones and a novel synthesis of furans by an unusual cycloaddition of diaryl ketenes with internal alkynes have been developed. These reactions proceed smoothly with the same rhodium catalyst, RhCl(PPh(3))(3), and are highly dependent on the structure and reactivity of the starting ketenes.
متن کاملEffect of ester on rhodium-catalyzed intermolecular [5+2] cycloaddition of 3-acyloxy-1,4-enynes and alkynes.
We systematically examined the effect of different esters on the rhodium-catalyzed intermolecular [5+2] cycloaddition of 3-acyloxy-1,4-enynes and alkynes with a concomitant 1,2-acyloxy migration. Significant rate acceleration was observed for benzoate substrates bearing an electron-donating substituent. The cycloaddition can now be conducted under much more practical conditions for most termina...
متن کاملNbCl(3)-catalyzed [2+2+2] intermolecular cycloaddition of alkynes and alkenes to 1,3-cyclohexadiene derivatives.
NbCl(3)(DME)-catalyzed [2+2+2] intermolecular cycloaddition of alkynes and alkenes was successfully achieved to give 1,4,5-trisubstituted-1,3-cyclohexadiene derivatives in good yields.
متن کاملNickel-catalyzed [2+2+1] cycloaddition of alkynes, acrylates and isocyanates.
Intermolecular [2+2+1] cycloaddition which incorporates an alkyne, an isocyanate, and an alkene into a γ-butyrolactam proceeds with nickel catalyst.
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2009
ISSN: 0040-4020
DOI: 10.1016/j.tet.2009.02.021